{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["Supplementary Table 2"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Supplementary Table 2","index":0,"n_rows":145,"n_cols":5,"rows_kept":145,"flags":["formulas_cached_only"]}
["Risk gene","Cor_IRG","Cor_coefficient","P-value","Regulation"]
["APLN","APLN",1,0,"postive"]
["APLN","ESM1",0.684,{"v":1.49148885020065e-52,"d":"1.49E-52"},"postive"]
["CDK4","ANGPTL3",-0.402,{"v":7.35493052935115e-16,"d":"7.35E-16"},"negative"]
["CDK4","AP3B1",0.506,{"v":1.61140351349079e-25,"d":"1.61E-25"},"postive"]
["CDK4","AZGP1",-0.452,{"v":4.91899953855839e-20,"d":"4.92E-20"},"negative"]
["CDK4","BCL10",0.552,{"v":5.68314297377342e-31,"d":"5.68E-31"},"postive"]
["CDK4","BRD8",0.429,{"v":4.98139696922013e-18,"d":"4.98E-18"},"postive"]
["CDK4","CASP3",0.501,{"v":5.20583094557964e-25,"d":"5.21E-25"},"postive"]
["CDK4","CDC42",0.45,{"v":7.11329567375465e-20,"d":"7.11E-20"},"postive"]
["CDK4","CDK4",1,0,"postive"]
["CDK4","CMTM3",0.47,{"v":9.55884917553762e-22,"d":"9.56E-22"},"postive"]
["CDK4","CMTM7",0.467,{"v":1.5635417027173e-21,"d":"1.56E-21"},"postive"]
["CDK4","CSF3R",0.452,{"v":4.19937759799012e-20,"d":"4.20E-20"},"postive"]
["CDK4","GDF11",0.429,{"v":5.31510121421878e-18,"d":"5.32E-18"},"postive"]
["CDK4","GMFB",0.471,{"v":7.061834583317e-22,"d":"7.06E-22"},"postive"]
["CDK4","GRB2",0.63,{"v":1.90140200454841e-42,"d":"1.90E-42"},"postive"]
["CDK4","GRN",0.542,{"v":1.13798315634957e-29,"d":"1.14E-29"},"postive"]
["CDK4","HDGF",0.405,{"v":4.38626227959957e-16,"d":"4.39E-16"},"postive"]
["CDK4","HSP90AB1",0.539,{"v":2.67291737237246e-29,"d":"2.67E-29"},"postive"]
["CDK4","HSPA8",0.484,{"v":3.73857569702516e-23,"d":"3.74E-23"},"postive"]
["CDK4","IFNGR2",0.522,{"v":2.89383264616407e-27,"d":"2.89E-27"},"postive"]
["CDK4","KITLG",0.449,{"v":8.05268359868658e-20,"d":"8.05E-20"},"postive"]
["CDK4","KRAS",0.447,{"v":1.17503950479313e-19,"d":"1.18E-19"},"postive"]
["CDK4","MALT1",0.538,{"v":2.93416845502496e-29,"d":"2.93E-29"},"postive"]
["CDK4","MAP2K1",0.439,{"v":7.20894378456903e-19,"d":"7.21E-19"},"postive"]
["CDK4","MAPK1",0.51,{"v":5.39845717555395e-26,"d":"5.40E-26"},"postive"]
["CDK4","MAPK3",0.474,{"v":3.38899722081933e-22,"d":"3.39E-22"},"postive"]
["CDK4","MICB",0.427,{"v":6.51505239329528e-18,"d":"6.52E-18"},"postive"]
["CDK4","NCK1",0.431,{"v":3.41328544681725e-18,"d":"3.41E-18"},"postive"]
["CDK4","NCK2",0.487,{"v":1.70382547121296e-23,"d":"1.70E-23"},"postive"]
["CDK4","NFATC2",0.497,{"v":1.50524273641164e-24,"d":"1.51E-24"},"postive"]
["CDK4","NFKB1",0.505,{"v":2.16017929336302e-25,"d":"2.16E-25"},"postive"]
["CDK4","NFYA",0.572,{"v":1.15934595688931e-33,"d":"1.16E-33"},"postive"]
["CDK4","NR2C2",0.409,{"v":2.24302807353816e-16,"d":"2.24E-16"},"postive"]
["CDK4","NRAS",0.568,{"v":4.91591809599116e-33,"d":"4.92E-33"},"postive"]
["CDK4","PAK1",0.413,{"v":1.01708529028647e-16,"d":"1.02E-16"},"postive"]
["CDK4","PAK2",0.437,{"v":1.02987564495733e-18,"d":"1.03E-18"},"postive"]
["CDK4","PAK4",0.65,{"v":7.82918436226306e-46,"d":"7.83E-46"},"postive"]
["CDK4","PDGFRL",0.408,{"v":2.62771807035804e-16,"d":"2.63E-16"},"postive"]
["CDK4","PLAU",0.407,{"v":2.85683050289201e-16,"d":"2.86E-16"},"postive"]
["CDK4","PLAUR",0.442,{"v":3.68100116055419e-19,"d":"3.68E-19"},"postive"]
["CDK4","PLCG1",0.569,{"v":3.53807000992964e-33,"d":"3.54E-33"},"postive"]
["CDK4","PLXNA1",0.612,{"v":2.00768152180349e-39,"d":"2.01E-39"},"postive"]
["CDK4","PLXNA3",0.462,{"v":5.19976679905608e-21,"d":"5.20E-21"},"postive"]
["CDK4","PSMD10",0.569,{"v":3.70457097067855e-33,"d":"3.70E-33"},"postive"]
["CDK4","PSMD14",0.439,{"v":6.0434354638522e-19,"d":"6.04E-19"},"postive"]
["CDK4","PSMD2",0.562,{"v":2.89827350287092e-32,"d":"2.90E-32"},"postive"]
["CDK4","PSMD3",0.418,{"v":4.30238345721113e-17,"d":"4.30E-17"},"postive"]
["CDK4","PSMD5",0.411,{"v":1.43264427408226e-16,"d":"1.43E-16"},"postive"]
["CDK4","PSME3",0.605,{"v":2.36107354057734e-38,"d":"2.36E-38"},"postive"]
["CDK4","PTAFR",0.405,{"v":4.76437198151865e-16,"d":"4.76E-16"},"postive"]
["CDK4","PTPN11",0.425,{"v":1.14441710167855e-17,"d":"1.14E-17"},"postive"]
["CDK4","RAF1",0.419,{"v":3.37452239896609e-17,"d":"3.37E-17"},"postive"]
["CDK4","RFX5",0.403,{"v":6.16492937966656e-16,"d":"6.16E-16"},"postive"]
["CDK4","SEMA4C",0.591,{"v":2.82506432842089e-36,"d":"2.83E-36"},"postive"]
["CDK4","SYK",0.416,{"v":5.84882440109906e-17,"d":"5.85E-17"},"postive"]
["CDK4","TGFB1",0.431,{"v":3.30734250760198e-18,"d":"3.31E-18"},"postive"]
["CDK4","THRA",0.42,{"v":2.71992521273112e-17,"d":"2.72E-17"},"postive"]
["CDK4","TNFRSF21",0.411,{"v":1.54170787959446e-16,"d":"1.54E-16"},"postive"]
["CDK4","TXLNA",0.451,{"v":5.24403206691383e-20,"d":"5.24E-20"},"postive"]
["CDK4","VAV3",0.402,{"v":7.50582653442927e-16,"d":"7.51E-16"},"postive"]
["CXCL2","CXCL1",0.401,{"v":9.61847520842792e-16,"d":"9.62E-16"},"postive"]
["CXCL2","CXCL2",1,0,"postive"]
["CXCL2","NAMPT",0.477,{"v":1.79632531448056e-22,"d":"1.80E-22"},"postive"]
["CXCL2","SAA1",0.479,{"v":1.00818477143262e-22,"d":"1.01E-22"},"postive"]
["ESR1","ADM2",-0.461,{"v":6.1160698460958e-21,"d":"6.12E-21"},"negative"]
["ESR1","AR",0.505,{"v":2.01506125772143e-25,"d":"2.02E-25"},"postive"]
["ESR1","BID",-0.436,{"v":1.2653446617002e-18,"d":"1.27E-18"},"negative"]
["ESR1","CAT",0.504,{"v":2.53581661831468e-25,"d":"2.54E-25"},"postive"]
["ESR1","CCL20",-0.423,{"v":1.58736806704443e-17,"d":"1.59E-17"},"negative"]
["ESR1","CKLF",-0.411,{"v":1.59987996694495e-16,"d":"1.60E-16"},"negative"]
["ESR1","ESR1",1,0,"postive"]
["ESR1","FAS",0.4,{"v":1.0439135835588e-15,"d":"1.04E-15"},"postive"]
["ESR1","FGFR3",-0.408,{"v":2.66799011088167e-16,"d":"2.67E-16"},"negative"]
["ESR1","FGFR4",-0.445,{"v":1.93174099380039e-19,"d":"1.93E-19"},"negative"]
["ESR1","HSPA4",-0.478,{"v":1.2899457755938e-22,"d":"1.29E-22"},"negative"]
["ESR1","IL27",0.44,{"v":5.34644404575815e-19,"d":"5.35E-19"},"postive"]
["ESR1","MDK",-0.438,{"v":8.07201618579866e-19,"d":"8.07E-19"},"negative"]
["ESR1","NMB",-0.421,{"v":2.10615248737659e-17,"d":"2.11E-17"},"negative"]
["ESR1","NR1I2",0.426,{"v":8.94954952874338e-18,"d":"8.95E-18"},"postive"]
["ESR1","RFXANK",-0.419,{"v":3.17608170881801e-17,"d":"3.18E-17"},"negative"]
["ESR1","RORA",0.438,{"v":7.83324993232046e-19,"d":"7.83E-19"},"postive"]
["ESR1","VEGFB",-0.411,{"v":1.52867849464284e-16,"d":"1.53E-16"},"negative"]
["IL1RN","IL1RN",1,0,"postive"]
["PSMD2","AP3B1",0.464,{"v":3.21889337206425e-21,"d":"3.22E-21"},"postive"]
["PSMD2","BCL10",0.455,{"v":2.49017531228117e-20,"d":"2.49E-20"},"postive"]
["PSMD2","CDC42",0.568,{"v":4.23040574612005e-33,"d":"4.23E-33"},"postive"]
["PSMD2","CDK4",0.562,{"v":2.89827350287092e-32,"d":"2.90E-32"},"postive"]
["PSMD2","CSF1",0.439,{"v":5.97570858301852e-19,"d":"5.98E-19"},"postive"]
["PSMD2","GRB2",0.562,{"v":2.63046100164417e-32,"d":"2.63E-32"},"postive"]
["PSMD2","GRN",0.595,{"v":6.68250673866226e-37,"d":"6.68E-37"},"postive"]
["PSMD2","HSP90AB1",0.439,{"v":6.23171566860035e-19,"d":"6.23E-19"},"postive"]
["PSMD2","HSPA8",0.507,{"v":1.35721505075833e-25,"d":"1.36E-25"},"postive"]
["PSMD2","MAP3K14",0.402,{"v":8.01371855644577e-16,"d":"8.01E-16"},"postive"]
["PSMD2","MAPK3",0.529,{"v":3.70669596747305e-28,"d":"3.71E-28"},"postive"]
["PSMD2","MICB",0.41,{"v":1.66107283094119e-16,"d":"1.66E-16"},"postive"]
["PSMD2","NCK1",0.406,{"v":3.56934521089288e-16,"d":"3.57E-16"},"postive"]
["PSMD2","NFKBIE",0.402,{"v":7.69024969039861e-16,"d":"7.69E-16"},"postive"]
["PSMD2","NRAS",0.516,{"v":1.28016200221303e-26,"d":"1.28E-26"},"postive"]
["PSMD2","PAK2",0.498,{"v":1.23447954966604e-24,"d":"1.23E-24"},"postive"]
["PSMD2","PLAUR",0.406,{"v":3.48664010858538e-16,"d":"3.49E-16"},"postive"]
["PSMD2","PLXNA1",0.502,{"v":4.66013443254161e-25,"d":"4.66E-25"},"postive"]
["PSMD2","PSMC4",0.479,{"v":1.18700086863334e-22,"d":"1.19E-22"},"postive"]
["PSMD2","PSMD10",0.483,{"v":4.11329852359204e-23,"d":"4.11E-23"},"postive"]
["PSMD2","PSMD13",0.454,{"v":2.97773079416613e-20,"d":"2.98E-20"},"postive"]
["PSMD2","PSMD14",0.598,{"v":2.09980112585462e-37,"d":"2.10E-37"},"postive"]
["PSMD2","PSMD2",1,0,"postive"]
["PSMD2","PSMD3",0.594,{"v":8.30531909225404e-37,"d":"8.31E-37"},"postive"]
["PSMD2","PSMD7",0.483,{"v":3.93968674125539e-23,"d":"3.94E-23"},"postive"]
["PSMD2","PSME3",0.581,{"v":6.14050998758668e-35,"d":"6.14E-35"},"postive"]
["PSMD2","PTAFR",0.406,{"v":3.79897475247819e-16,"d":"3.80E-16"},"postive"]
["PSMD2","RFX5",0.426,{"v":8.23758079745814e-18,"d":"8.24E-18"},"postive"]
["PSMD2","TAP1",0.439,{"v":7.06508453856892e-19,"d":"7.07E-19"},"postive"]
["PSMD2","THRA",0.479,{"v":1.00922034214187e-22,"d":"1.01E-22"},"postive"]
["PSMD2","TXLNA",0.567,{"v":6.92983962511818e-33,"d":"6.93E-33"},"postive"]
["SEMA3F","FLT1",0.423,{"v":1.66118475570919e-17,"d":"1.66E-17"},"postive"]
["SEMA3F","PDGFB",0.457,{"v":1.4437767907578e-20,"d":"1.44E-20"},"postive"]
["SEMA3F","SEMA3F",1,0,"postive"]
["SEMA3F","SEMA6B",0.428,{"v":6.01426109626001e-18,"d":"6.01E-18"},"postive"]
["SPP1","BCL10",0.417,{"v":5.22428519619071e-17,"d":"5.22E-17"},"postive"]
["SPP1","C3AR1",0.416,{"v":6.10893452077735e-17,"d":"6.11E-17"},"postive"]
["SPP1","C5AR1",0.413,{"v":1.05584982577755e-16,"d":"1.06E-16"},"postive"]
["SPP1","CKLF",0.405,{"v":4.5138640488804e-16,"d":"4.51E-16"},"postive"]
["SPP1","CLCF1",0.493,{"v":3.74605418712576e-24,"d":"3.75E-24"},"postive"]
["SPP1","CMTM7",0.473,{"v":4.69448593788703e-22,"d":"4.69E-22"},"postive"]
["SPP1","CSF1",0.443,{"v":3.18710905384935e-19,"d":"3.19E-19"},"postive"]
["SPP1","CXCL1",0.417,{"v":5.09145328154772e-17,"d":"5.09E-17"},"postive"]
["SPP1","CXCL6",0.41,{"v":1.70547183174211e-16,"d":"1.71E-16"},"postive"]
["SPP1","FCER1G",0.406,{"v":3.42434900300035e-16,"d":"3.42E-16"},"postive"]
["SPP1","GRN",0.404,{"v":5.28712874148254e-16,"d":"5.29E-16"},"postive"]
["SPP1","IFNGR2",0.434,{"v":1.94078793771535e-18,"d":"1.94E-18"},"postive"]
["SPP1","IL18",0.412,{"v":1.17448411094547e-16,"d":"1.17E-16"},"postive"]
["SPP1","IL27RA",0.408,{"v":2.4457522439957e-16,"d":"2.45E-16"},"postive"]
["SPP1","LIF",0.472,{"v":6.11189423320865e-22,"d":"6.11E-22"},"postive"]
["SPP1","LYN",0.538,{"v":3.07624330365189e-29,"d":"3.08E-29"},"postive"]
["SPP1","OSMR",0.463,{"v":3.799934914037e-21,"d":"3.80E-21"},"postive"]
["SPP1","PLAUR",0.444,{"v":2.26906101432885e-19,"d":"2.27E-19"},"postive"]
["SPP1","PLXNA1",0.424,{"v":1.29977588732233e-17,"d":"1.30E-17"},"postive"]
["SPP1","PSMD14",0.469,{"v":1.12243807519575e-21,"d":"1.12E-21"},"postive"]
["SPP1","PTAFR",0.405,{"v":4.5975950844713e-16,"d":"4.60E-16"},"postive"]
["SPP1","RELB",0.421,{"v":2.18847701441023e-17,"d":"2.19E-17"},"postive"]
["SPP1","S100A6",0.476,{"v":2.37875175984921e-22,"d":"2.38E-22"},"postive"]
["SPP1","SPP1",1,0,"postive"]
["SPP1","TNFRSF21",0.513,{"v":2.96092619639741e-26,"d":"2.96E-26"},"postive"]